The Sanctuary straddles the Ooty – Mysore inter-state Highway roughly midway between the two cities (Theppakadu being 91 km, from Mysore and 67 km, from Ooty) and could be approached with equal facility from either direction. From Theppakadu there are two routes to Ooty. One a short cut over the steep and narrow Sigur Ghat Road, which has a gradient of 1 in 10 in places and has to negotiated with care. Over this route Theppakadu is only 36 km from Ooty as against 67 km, over the Highway Via. Gudalur. The Sanctuary is well served by buses, particularly from Ooty. Long distance inter-state buses from Bangalore and Mysore pass through Theppakadu, Unless reservation is made in advance, it is difficult to board these buses at Theppakadu.
The nearest railhead to the south is Ooty and the most convenient railhead to the north is Mysore.
During the summer season, special buses are run to Mudumalai and back from Ooty. Tourist cars and vans are available on hire in the neighbouring towns. Bangalore and Coimbatore airports are 240 km, and 170 km, from Theppakadu respectively.